While navigating the landscape of the primary care clinic, there is a growing need to understand opioid reversal agents, both their mechanistic utility as well as their practical application. Based on the broad age-range of patients frequenting primary care clinics, coupled with growing incidence of pain medication prescription patterns, knowledge of potentially lifesaving Naloxone administration is a vital need for the associated healthcare professionals. This CE addresses such a need by providing those most likely to administer Naloxone with both the knowledge and the practical expertise for quick and safe administration in today’s primary care setting. This CE will be delivered in conjunction with Justin Weinstein, PharmD Candidate 2021.